haya.Learning made clear
Unit II · Diseases of the gastrointestinal tract
8 min readConcept sheetOften a 5- or 10-mark answer

Celiac disease

Celiac disease is an autoimmune reaction to gluten that flattens the villi of the small intestine. The only treatment is a strict, lifelong gluten-free diet.

TriggerGluten: gliadin in wheat, secalin in rye, hordein in barley
DamageVillous atrophy (flattened villi) in the small intestine, causing malabsorption
TreatmentStrict gluten-free diet for life
Gluten-free label20 mg gluten per kg (20 ppm) or less (Codex standard)

At a glance

DefinitionAn autoimmune disease in which gluten triggers damage to the lining of the small intestine in genetically prone people
CausesGluten in the diet + genes (HLA-DQ2 or DQ8) + immune response; runs in families; in India seen more in the wheat-eating north
Classic symptomsChronic diarrhoea, pale bulky fatty stools (steatorrhoea), bloating, weight loss; in children a swollen belly and poor growth
Other signsAnaemia that does not improve with iron, short stature, weak bones, delayed puberty, mouth ulcers, an itchy blistering rash (dermatitis herpetiformis)
DiagnosisBlood test for tTG antibodies and biopsy of the small intestine, done while the patient still eats gluten

Dietary principles

PointRecommendationWhy
GlutenRemove wheat, barley and rye completely, for life; oats only if certified uncontaminated and toleratedEven small amounts keep the villi damaged
Energy and proteinHigh at first to regain lost weight and growthMalabsorption causes weight loss and wasting
FatLow at first if stools are fatty; normal once the gut healsFat is poorly absorbed while villi are flat
LactoseLimit milk for the first weeks; use curdDamaged villi make less lactase; this usually recovers
Vitamins and mineralsIron, folate, B12, calcium, vitamin D, zinc, fat-soluble vitaminsThese are poorly absorbed and often deficient
FibreUse millets, pulses, vegetables and fruitsGluten-free diets made only of rice and potato can be low in fibre

Foods allowed, hidden gluten and foods to avoid

GroupAllowed (gluten-free)Avoid (contain gluten)
Cereals and milletsRice, ragi, jowar, bajra, maize, foxtail and other millets, rajgira (amaranth), kuttu (buckwheat), quinoa, sabudana, arrowrootWheat atta, maida, suji or rava, dalia, seviyan, barley, rye
Pulses and floursAll dals, besan, urad and moong floursMixed flours with wheat
Bakery and snacksSnacks made at home from rice, besan or milletsBread, biscuits, cakes, rusk, pizza, noodles, pasta, samosa, batter-fried snacks
Hidden glutenRead every labelMalted health drinks (barley malt), some hing (mixed with wheat flour), soy sauce, packet soups, sauces thickened with flour, beer
OthersMilk, curd, paneer, egg, meat, fish, vegetables, fruits, nuts, oilsCross-contamination: shared flour mill (chakki), toaster, frying oil

Sample one-day gluten-free menu

MealMenu
Early morningMilk (or curd in the first weeks) with a few almonds
BreakfastRagi dosa or rice idli (3) with sambar and coconut chutney
Mid-morningGuava or banana
LunchRice, rajma or dal, palak poriyal, cucumber raita
EveningBesan chilla or roasted makhana; buttermilk
DinnerJowar or bajra roti (2), chicken or paneer curry (no flour thickening), mixed vegetables
BedtimeRice kheer or milk
At the bedside

In a hospital kitchen, a celiac patient's food needs a separate tawa, ladle and flour; one roti dusted with atta can undo the diet. Teach the family to read labels for wheat, barley, malt and hing.

Exam angle

2 marks: “What is gluten? Name two cereals that contain it.” Gluten is the protein complex (gliadin and glutenin) of wheat that triggers celiac disease; also present in barley and rye.

5 marks: “List gluten-free foods and sources of hidden gluten.” Rice, millets, maize, sabudana, pulses, milk, eggs, meat, vegetables; hidden in malted drinks, hing, soy sauce, packet soups, bakery items.

10 marks: “Discuss the causes, symptoms and dietary management of celiac disease. Plan a gluten-free menu.” Define, causes, villous atrophy, symptoms, diagnosis, principles table, allowed and avoided foods with hidden gluten, a one-day menu.

Remember it

Avoid BROW: Barley, Rye, Oats (unless certified pure), Wheat.